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Our goal is to better understand the immune microenvironment in cancers utilizing advanced methodologies including in vivo imaging and single-cell genomics.

In particular, we aim to unveil the immense potential of myeloid populations in cancers. Real-time intravital multi-photon microscopy provides insight into dynamic cell migration and intercellular communication. We reveal the heterogeneity of myeloid cells through single-cell RNA sequencing in both pre-clinical and clinical specimens. This approach will provide novel avenues for immunotherapy of cancers by means of identifying promising targets in tumor immunity.