Publications

Incio J, Ligibel JA, McManus DT, Suboj P, Jung K, Kawaguchi K, Pinter M, Babykutty S, Chin SM, Vardam TD, Huang Y, Rahbari NN, Roberge S, Wang D, Gomes-Santos IL, Puchner SB, Schlett CL, Hoffmman U, Ancukiewicz M, Tolaney SM, Krop IE, Duda DG, Boucher Y, Fukumura D, Jain RK.

Sci Transl Med. 2018 Mar 14;10(432). pii: eaag0945. doi: 10.1126/scitranslmed.aag0945. PMID: 29540614

Methicillin-resistant Staphylococcus aureus causes sustained collecting lymphatic vessel dysfunction.

Jones D, Meijer EFJ, Blatter C, Liao S, Pereira ER, Bouta EM, Jung K, Chin SM, Huang P, Munn LL, Vakoc BJ, Otto M, Padera TP.

Sci Transl Med. 2018 Jan 17;10(424). pii: eaam7964. doi: 10.1126/scitranslmed.aam7964. PMID: 29343625

2017

Targeting CXCR4-dependent immunosuppressive Ly6C(low) monocytes improves antiangiogenic therapy in colorectal cancer.

Jung K, Heishi T, Incio J, Huang Y, Beech EY, Pinter M, Ho WW, Kawaguchi K, Rahbari NN, Chung E, Kim JK, Clark JW, Willett CG, Yun SH, Luster AD, Padera TP, Jain RK, Fukumura D.

Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):10455-10460. doi: 10.1073/pnas.1710754114. PMID: 28900008

Ly6C(lo) monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy.

Jung K, Heishi T, Khan OF, Kowalski PS, Incio J, Rahbari NN, Chung E, Clark JW, Willett CG, Luster AD, Yun SH, Langer R, Anderson DG, Padera TP, Jain RK, Fukumura D.

J Clin Invest. 2017 Aug 1;127(8):3039-3051. doi: 10.1172/JCI93182. PMID: 28691930

Lymph node effective vascular permeability and chemotherapy uptake.

Meijer EFJ, Blatter C, Chen IX, Bouta E, Jones D, Pereira ER, Jung K, Vakoc BJ, Baish JW, Padera TP.

Microcirculation. 2017 Aug;24(6). doi: 10.1111/micc.12381. PMID: 28510992

2016

Live Images of Donor Dendritic Cells Trafficking via CX3CR1 Pathway.

Ueno T, Kim P, McGrath MM, Yeung MY, Shimizu T, Jung K, Sayegh MH, Chandraker AK, Abdi R, Yun SH.

Front Immunol. 2016 Oct 14;7:412. PMID: 27790214

Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases.

Rahbari NN, Kedrin D, Incio J, Liu H, Ho WW, Nia HT, Edrich CM, Jung K, Daubriac J, Chen I, Heishi T, Martin JD, Huang Y, Maimon N, Reissfelder C, Weitz J, Boucher Y, Clark JW, Grodzinsky AJ, Duda DG, Jain RK, Fukumura D.

Sci Transl Med. 2016 Oct 12;8(360):360ra135. PMID: 27733559

Imaging cell biology in transplantation.

Ueno T, Jung K, Yeung MY, McGrath MM, Shimizu T, Kim P, Sayegh MH, Chandraker A, Yun SH.

Transpl Int. 2016 Dec;29(12):1349-1351. doi: 10.1111/tri.12852. PMID: 27570933

Obesity-Induced Inflammation and Desmoplasia Promote Pancreatic Cancer Progression and Resistance to Chemotherapy.

Incio J, Liu H, Suboj P, Chin SM, Chen IX, Pinter M, Ng MR, Nia HT, Grahovac J, Kao S, Babykutty S, Huang Y, Jung K, Rahbari NN, Han X, Chauhan VP, Martin JD, Kahn J, Huang P, Desphande V, Michaelson J, Michelakos TP, Ferrone CR, Soares R, Boucher Y, Fukumura D, Jain RK.

Cancer Discov. 2016 Aug;6(8):852-69. doi: 10.1158/2159-8290.CD-15-1177. PMID: 27246539

Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival.

Kloepper J, Riedemann L, Amoozgar Z, Seano G, Susek K, Yu V, Dalvie N, Amelung RL, Datta M, Song JW, Askoxylakis V, Taylor JW, Lu-Emerson C, Batista A, Kirkpatrick ND, Jung K, Snuderl M, Muzikansky A, Stubenrauch KG, Krieter O, Wakimoto H, Xu L, Munn LL, Duda DG, Fukumura D, Batchelor TT, Jain RK.

Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):4476-81. doi: 10.1073/pnas.1525360113. PMID: 27044098

Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages.

Peterson TE, Kirkpatrick ND, Huang Y, Farrar CT, Marijt KA, Kloepper J, Datta M, Amoozgar Z, Seano G, Jung K, Kamoun WS, Vardam T, Snuderl M, Goveia J, Chatterjee S, Batista A, Muzikansky A, Leow CC, Xu L, Batchelor TT, Duda DG, Fukumura D, Jain RK.

Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):4470-5. doi: 10.1073/pnas.1525349113. PMID: 27044097

PlGF/VEGFR-1 Signaling Promotes Macrophage Polarization and Accelerated Tumor Progression in Obesity.

Incio J, Tam J, Rahbari NN, Suboj P, McManus DT, Chin SM, Vardam TD, Batista A, Babykutty S, Jung K, Khachatryan A, Hato T, Ligibel JA, Krop IE, Puchner SB, Schlett CL, Hoffmman U, Ancukiewicz M, Shibuya M, Carmeliet P, Soares R, Duda DG, Jain RK, Fukumura D.

Clin Cancer Res. 2016 Jun 15;22(12):2993-3004. doi: 10.1158/1078-0432.CCR-15-1839. PMID: 26861455

Solid stress and elastic energy as measures of tumour mechanopathology.

Nia HT, Liu H, Seano G, Datta M, Jones D, Rahbari N, Incio J, Chauhan VP, Jung K, Martin JD, Askoxylakis V, Padera TP, Fukumura D, Boucher Y, Hornicek FJ, Grodzinsky AJ, Baish JW, Munn LL, Jain RK.

Nat Biomed Eng. 2016;1. pii: 0004. doi: 10.1038/s41551-016-0004. PMID: 28966873

2015

Designed angiopoietin-1 variant, COMP-angiopoietin-1, rescues erectile function through healthy cavernous angiogenesis in a hypercholesterolemic mouse.

Ryu JK, Kim WJ, Koh YJ, Piao S, Jin HR, Lee SW, Choi MJ, Shin HY, Kwon MH, Jung K, Koh GY, Suh JK.

Sci Rep. 2015 Mar 18;5:9222. doi: 10.1038/srep09222. PMID: 25783805

The lymph node microenvironment and its role in the progression of metastatic cancer.

Pereira ER, Jones D, Jung K, Padera TP.

Semin Cell Dev Biol. 2015 Feb;38:98-105. doi: 10.1016/j.semcdb.2015.01.008. Review. PMID: 25620792

2013

Endoscopic time-lapse imaging of immune cells in infarcted mouse hearts.

Jung K, Kim P, Leuschner F, Gorbatov R, Kim JK, Ueno T, Nahrendorf M, Yun SH.

Circ Res. 2013 Mar 15;112(6):891-9. doi: 10.1161/CIRCRESAHA.111.300484. PMID: 23392842

2012

In vivo imaging of tracheal epithelial cells in mice during airway regeneration.

Kim JK, Vinarsky V, Wain J, Zhao R, Jung K, Choi J, Lam A, Pardo-Saganta A, Breton S, Rajagopal J, Yun SH.

Am J Respir Cell Mol Biol. 2012 Dec;47(6):864-8. doi: 10.1165/rcmb.2012-0164OC. PMID: 22984086

Fabrication and operation of GRIN probes for in vivo fluorescence cellular imaging of internal organs in small animals.

Kim JK, Lee WM, Kim P, Choi M, Jung K, Kim S, Yun SH.

Nat Protoc. 2012 Jul 5;7(8):1456-69. doi: 10.1038/nprot.2012.078. PMID: 22767088

2011

Double anti-angiogenic and anti-inflammatory protein Valpha targeting VEGF-A and TNF-alpha in retinopathy and psoriasis.

Jung K, Lee D, Lim HS, Lee SI, Kim YJ, Lee GM, Kim SC, Koh GY.

J Biol Chem. 2011 Apr 22;286(16):14410-8. doi: 10.1074/jbc.M111.228130. PMID: 21345791

2010

Double antiangiogenic protein, DAAP, targeting VEGF-A and angiopoietins in tumor angiogenesis, metastasis, and vascular leakage.

Koh YJ, Kim HZ, Hwang SI, Lee JE, Oh N, Jung K, Kim M, Kim KE, Kim H, Lim NK, Jeon CJ, Lee GM, Jeon BH, Nam DH, Sung HK, Nagy A, Yoo OJ, Koh GY.

Cancer Cell. 2010 Aug 9;18(2):171-84. doi: 10.1016/j.ccr.2010.07.001. PMID: 20708158

2009

Toll-like receptor 4 decoy, TOY, attenuates gram-negative bacterial sepsis.

Jung K, Lee JE, Kim HZ, Kim HM, Park BS, Hwang SI, Lee JO, Kim SC, Koh GY.

PLoS One. 2009 Oct 9;4(10):e7403. doi: 10.1371/journal.pone.0007403. PMID: 19816595

Critical role of CD11b+ macrophages and VEGF in inflammatory lymphangiogenesis, antigen clearance, and inflammation resolution.

Kataru RP, Jung K, Jang C, Yang H, Schwendener RA, Baik JE, Han SH, Alitalo K, Koh GY.

Blood. 2009 May 28;113(22):5650-9. doi: 10.1182/blood-2008-09-176776. PMID: 19346498

A designed angiopoietin-2 variant, pentameric COMP-Ang2, strongly activates Tie2 receptor and stimulates angiogenesis.

Kim HZ, Jung K, Kim HM, Cheng Y, Koh GY.

Biochim Biophys Acta. 2009 May;1793(5):772-80. doi: 10.1016/j.bbamcr.2009.01.018. PMID: 19339208

2008

Profound but dysfunctional lymphangiogenesis via vascular endothelial growth factor ligands from CD11b+ macrophages in advanced ovarian cancer.

Jeon BH, Jang C, Han J, Kataru RP, Piao L, Jung K, Cha HJ, Schwendener RA, Jang KY, Kim KS, Alitalo K, Koh GY.

Cancer Res. 2008 Feb 15;68(4):1100-9. doi: 10.1158/0008-5472.CAN-07-2572. PMID: 18281485