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Publications

2026
2026

Metabolic Reprogramming of Myeloid Cells in Cancer: From Lactate-NAMPT Axis to AI-Guided Therapeutics

Lee IG, Jung K

Experimental & Molecular Medicine. in press

VISTA drives pancreatic tumor progression through modulation of the tumor-associated macrophage polarity

Shin SK, Kim G, Park SM, Sea EB, Ye SK, Kang GH, Jung K, Shin HM, Kim HR, Lee DS

Nature Communications. 2026 Mar 03; doi: 10.1038/s41467-026-70215-7 

Controlled-release nanoparticle of toll-like receptors-7/8 agonist enhances immune activation and inhibits gastric cancer in a preclinical mouse model

Kim HM, Jeong K, Jeong J, Jin SM, Yoo J, Yoo YR, Shin JY, Park DJ, Lee HJ, Yang HK, Lee HS, Oh DY, Lim YT, Jung K*, Kong SH* (*co-corresponding authors).

Cancer Cell International. 2026 Feb 09; doi: 10.1186/s12935-026-04191-9

2025
2025

Single-cell transcriptomics of the myeloid milieu reveals an angiogenic niche in triple-negative breast cancer

Choi Y, Shim M, Kim SH, Kim DK, Jeong J, Byeon J, Jang G, Kim JY, Robson P, Lee C*, Lee HB*, Jung K* (*co-corresponding authors).

Experimental & Molecular Medicine. 2025 Nov 07; doi: 10.1038/s12276-025-01571-5

Proteogenomic characterization of molecular and cellular targets for treatment-resistant subtypes in locally advanced cervical cancers

Hyeon DY, Nam D, Shin HJ, Jeong J, Jung E, Cho SY, Shin DH, Ku JL, Baek HJ, Yoo CW, Hong EK, Lim MC, Lee SJ, Bae YK, Kim JK, Bae J, 

Kim SJ, Back S, Kang C, Madar IH, Kim H, Kim S, Kim DK, Kang J, Park GW, Park KS, Shin Y, Kim SS*, Jung K*, Hwang D*, Lee SW*,Kim JY* (*co-corresponding authors).

Molecular Cancer. 2025 Mar 14; doi: 10.1186/s12943-025-02256-3

High-Throughput Chemotherapeutic Drug Screening System for Gastric Cancer (Cure-GA)

Lee J, Kim IH, Seol D, Lee S, Yoo M, Lee TK, Yoon SH, Lee E, Hwang D, Kang SH, Park YS, Ku B, Jeon SY, Choi Y, Jung K, Kim JW, Kim JW, Ahn SH, Lee KW, Kim HH, Jeong H, Lee DW, Suh YS

Annals of Surgcial Oncology. 2025 Jan 23; doi: 10.1245/s10434-024-16850-0

2023
2023

Normalization of the Tumor Microenvironment by Harnessing Vascular and Immune Modulation to Achieve Enhanced Cancer Therapy

Choi Y, Jung K. 

Experimental & Molecular Medicine. 2023 Nov 1; doi: 10.1038/s12276-023-01114-w

Proteogenomic landscape of human pancreatic ductal adenocarcinoma in an Asian population reveals tumor cell-enriched and immune-rich subtypes

Hyeon DY, Nam D, Han Y, Kim DK, Kim G, Kim D, Bae J, Back S, Mun DG, Madar IH, Lee H, Kim SJ, Kim H, Hyun S, Kim CR, Choi SA, Kim YR, Jeong J, Jeon S, Choo YW, Lee KB, Kwon W, Choi S, Goo T, Park T, Suh YA, Kim H, Ku JL, Kim MS, Paek E, Park D*, Jung K*, Baek SH*, Jang JY*, Hwang D*, Lee SW* (* co-corresponding authors).

Nature Cancer. 2023 Feb 1; doi: 10.1038/s43018-022-00479-7.

2022
2022

Risk stratification of patients with right-sided colorectal cancer based on the tumor-infiltrating M1 macrophage

Lim DM, Kang J, Woo S, Choi H, Kwon M, Kim J, Park HR, Jung K, Baryawno N*, Kim H*, Lee D*, Kim YH* (* co-corresponding authors).

American Journal of Cancer Research. 2022 Dec 15;12(12):5532-5551. PMID: 36628292.

PD-L1-directed PlGF/VEGF blockade synergizes with chemotherapy by targeting CD141+ cancer-associated fibroblasts in pancreatic cancer.

Kim DK, Jeong J, Lee DS, Hyeon DY, Park GW, Jeon S, Lee KB, Jang JY, Hwang D, Kim HM*, Jung K* (* co-corresponding authors).

Nature Communications. 2022 Oct 22; doi: 10.1038/s41467-022-33991-6.

MarcoPolo: a method to discover differentially expressed genes in single-cell RNA-seq data without depending on prior clustering.

Kim C, Lee H, Jeong J, Jung K*, Han B* (* co-corresponding authors).

Nucleic Acids Research. 2022 Apr 14; doi: 10.1093/nar/gkac216. 

Microbial and molecular differences according to the location of head and neck cancers.

Kim YK, Kwon EJ, Yu Y, Kim J, Woo SY, Choi HS, Kwon M, Jung K, Kim HS, Park HR, Lee D, Kim YH.

Cancer Cell Int. 2022 Mar 26; doi: 10.1186/s12935-022-02554-6.

2021
2021

Nano-assembly of a Chemically Tailored Cas9 Ribonucleoprotein for In Vivo Gene Editing and Cancer Immunotherapy. 

Lee J, Kang YK, Oh E, Jeong J, Im SH, Kim DK, Lee H, Kim SG, Jung K*, Chung HJ* (* co-corresponding authors).

Chemistry of Materials. 2021 Dec 20; doi: 10.1021/acs.chemmater.1c02844. 

OASL1-Mediated Inhibition of Type I IFN Reduces Influenza A Infection-Induced Airway Inflammation by Regulating ILC2s. 

Chang Y, Kang JS, Jung K, Chung DH, Ha SJ, Kim YJ, Kim HY.

Allergy Asthma Immunol Research. 2021 Dec 15; doi: 10.4168/aair.2022.14.1.99. 

Mesenchymal Stem Cells Suppress Severe Asthma by Directly Regulating Th2 Cells and Type 2 Innate Lymphoid Cells.

Shin JW, Ryu S, Ham J, Jung K, Lee S, Chung DH, Kang HR, Kim HY.

Molecules and Cells. 2021 Aug 23; doi: 10.14348/molcells.2021.0101. 

Tumor-Infiltrating Neutrophils and Non-Classical Monocytes May Be Potential Therapeutic Targets for HER2negative Gastric Cancer. 

Jeong J, Kim DK, Park JH, Park DJ, Lee HJ, Yang HK, Kong SH, Jung K.

Immune Network. 2021 Aug 20; doi: 10.4110/in.2021.21.e31. 

Mobility of Nucleostemin in Live Cells Is Specifically Related to Transcription Inhibition by Actinomycin D and GTP-Binding Motif. 

Pack CG, Jung K, Paulson B, Kim JK.

International Journal of Molecular Sciences. 2021 Aug 2; doi: 10.3390/ijms22158293. 

Cas9 conjugate complex delivering donor DNA for efficient gene editing by homology-directed repair. 

Kang YK, Lee J, Im SH, Lee JH, Jeong J, Kim DK, Yang SY, Jung K*, Kim SG*, Chung HJ* (* co-corresponding authors).

Journal of Industrial and Engineering Chemistry. 2021 Jul 14; doi: 10.1016/j.jiec.2021.07.009. 

Longitudinal Analysis of Human Memory T-Cell Response according to the Severity of Illness up to 8 Months after SARS-CoV-2 Infection. 

Kang CK, Kim M, Lee S, Kim G, Choe PG, Park WB, Kim NJ, Lee CH, Kim IS, Jung K, Lee DS, Shin HM, Kim HR, Oh M.

The Journal of Infectious Diseases. 2021 Mar 23; doi: 10.1093/infdis/jiab159. 

Development of an antibody-like T-cell engager based on VH-VL heterodimer formation and its application in cancer therapy.

Jang S, Song J, Kim NY, Bak J, Jung K, Park YW, Park BC, Kim HM.

Biomaterials. 2021 Mar 13; doi: 10.1016/j.biomaterials.2021.120760. 

2020
2019
2018
2018

Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2.

Incio J, Ligibel JA, McManus DT, Suboj P, Jung K, Kawaguchi K, Pinter M, Babykutty S, Chin SM, Vardam TD, Huang Y, Rahbari NN, Roberge S, Wang D, Gomes-Santos IL, Puchner SB, Schlett CL, Hoffmman U, Ancukiewicz M, Tolaney SM, Krop IE, Duda DG, Boucher Y, Fukumura D, Jain RK.

Sci Transl Med. 2018 Mar 14;10(432). pii: eaag0945. doi: 10.1126/scitranslmed.aag0945. PMID: 29540614

Methicillin-resistant Staphylococcus aureus causes sustained collecting lymphatic vessel dysfunction.

Jones D, Meijer EFJ, Blatter C, Liao S, Pereira ER, Bouta EM, Jung K, Chin SM, Huang P, Munn LL, Vakoc BJ, Otto M, Padera TP.

Sci Transl Med. 2018 Jan 17;10(424). pii: eaam7964. doi: 10.1126/scitranslmed.aam7964. PMID:  29343625​

2017
2017

Targeting CXCR4-dependent immunosuppressive Ly6C(low) monocytes improves antiangiogenic therapy in colorectal cancer.

Jung K, Heishi T, Incio J, Huang Y, Beech EY, Pinter M, Ho WW, Kawaguchi K, Rahbari NN, Chung E, Kim JK, Clark JW, Willett CG, Yun SH, Luster AD, Padera TP, Jain RK, Fukumura D.

Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):10455-10460. doi: 10.1073/pnas.1710754114. PMID: 28900008

Ly6C(lo) monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy.

Jung K, Heishi T, Khan OF, Kowalski PS, Incio J, Rahbari NN, Chung E, Clark JW, Willett CG, Luster AD, Yun SH, Langer R, Anderson DG, Padera TP, Jain RK, Fukumura D.

J Clin Invest. 2017 Aug 1;127(8):3039-3051. doi: 10.1172/JCI93182. PMID: 28691930

Lymph node effective vascular permeability and chemotherapy uptake.

Meijer EFJ, Blatter C, Chen IX, Bouta E, Jones D, Pereira ER, Jung K, Vakoc BJ, Baish JW, Padera TP.

Microcirculation. 2017 Aug;24(6). doi: 10.1111/micc.12381. PMID: 28510992

2016
2016

Live Images of Donor Dendritic Cells Trafficking via CX3CR1 Pathway.

Ueno T, Kim P, McGrath MM, Yeung MY, Shimizu T, Jung K, Sayegh MH, Chandraker AK, Abdi R, Yun SH.

Front Immunol. 2016 Oct 14;7:412. PMID: 27790214

Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases.

Rahbari NN, Kedrin D, Incio J, Liu H, Ho WW, Nia HT, Edrich CM, Jung K, Daubriac J, Chen I, Heishi T, Martin JD, Huang Y, Maimon N, Reissfelder C, Weitz J, Boucher Y, Clark JW, Grodzinsky AJ, Duda DG, Jain RK, Fukumura D.

Sci Transl Med. 2016 Oct 12;8(360):360ra135. PMID: 27733559

Imaging cell biology in transplantation.

Ueno T, Jung K, Yeung MY, McGrath MM, Shimizu T, Kim P, Sayegh MH, Chandraker A, Yun SH.

Transpl Int. 2016 Dec;29(12):1349-1351. doi: 10.1111/tri.12852. PMID: 27570933

Obesity-Induced Inflammation and Desmoplasia Promote Pancreatic Cancer Progression and Resistance to Chemotherapy.

Incio J, Liu H, Suboj P, Chin SM, Chen IX, Pinter M, Ng MR, Nia HT, Grahovac J, Kao S, Babykutty S, Huang Y, Jung K, Rahbari NN, Han X, Chauhan VP, Martin JD, Kahn J, Huang P, Desphande V, Michaelson J, Michelakos TP, Ferrone CR, Soares R, Boucher Y, Fukumura D, Jain RK.

Cancer Discov. 2016 Aug;6(8):852-69. doi: 10.1158/2159-8290.CD-15-1177. PMID: 27246539

Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival.

Kloepper J, Riedemann L, Amoozgar Z, Seano G, Susek K, Yu V, Dalvie N, Amelung RL, Datta M, Song JW, Askoxylakis V, Taylor JW, Lu-Emerson C, Batista A, Kirkpatrick ND, Jung K, Snuderl M, Muzikansky A, Stubenrauch KG, Krieter O, Wakimoto H, Xu L, Munn LL, Duda DG, Fukumura D, Batchelor TT, Jain RK.

Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):4476-81. doi: 10.1073/pnas.1525360113. PMID: 27044098

Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages.

Peterson TE, Kirkpatrick ND, Huang Y, Farrar CT, Marijt KA, Kloepper J, Datta M, Amoozgar Z, Seano G, Jung K, Kamoun WS, Vardam T, Snuderl M, Goveia J, Chatterjee S, Batista A, Muzikansky A, Leow CC, Xu L, Batchelor TT, Duda DG, Fukumura D, Jain RK.

Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):4470-5. doi: 10.1073/pnas.1525349113. PMID: 27044097

PlGF/VEGFR-1 Signaling Promotes Macrophage Polarization and Accelerated Tumor Progression in Obesity.

Incio J, Tam J, Rahbari NN, Suboj P, McManus DT, Chin SM, Vardam TD, Batista A, Babykutty S, Jung K, Khachatryan A, Hato T, Ligibel JA, Krop IE, Puchner SB, Schlett CL, Hoffmman U, Ancukiewicz M, Shibuya M, Carmeliet P, Soares R, Duda DG, Jain RK, Fukumura D.

Clin Cancer Res. 2016 Jun 15;22(12):2993-3004. doi: 10.1158/1078-0432.CCR-15-1839. PMID: 26861455

Solid stress and elastic energy as measures of tumour mechanopathology.

Nia HT, Liu H, Seano G, Datta M, Jones D, Rahbari N, Incio J, Chauhan VP, Jung K, Martin JD, Askoxylakis V, Padera TP, Fukumura D, Boucher Y, Hornicek FJ, Grodzinsky AJ, Baish JW, Munn LL, Jain RK.

Nat Biomed Eng. 2016;1. pii: 0004. doi: 10.1038/s41551-016-0004. PMID:  28966873

2015
2015

Designed angiopoietin-1 variant, COMP-angiopoietin-1, rescues erectile function through healthy cavernous angiogenesis in a hypercholesterolemic mouse.

Ryu JK, Kim WJ, Koh YJ, Piao S, Jin HR, Lee SW, Choi MJ, Shin HY, Kwon MH, Jung K, Koh GY, Suh JK.

Sci Rep. 2015 Mar 18;5:9222. doi: 10.1038/srep09222. PMID:  25783805

The lymph node microenvironment and its role in the progression of metastatic cancer.

Pereira ER, Jones D, Jung K, Padera TP.

Semin Cell Dev Biol. 2015 Feb;38:98-105. doi: 10.1016/j.semcdb.2015.01.008. Review. PMID: 25620792

2013
2013

Endoscopic time-lapse imaging of immune cells in infarcted mouse hearts.

Jung K, Kim P, Leuschner F, Gorbatov R, Kim JK, Ueno T, Nahrendorf M, Yun SH.

Circ Res. 2013 Mar 15;112(6):891-9. doi: 10.1161/CIRCRESAHA.111.300484. PMID:  23392842

2012
2012

In vivo imaging of tracheal epithelial cells in mice during airway regeneration.

Kim JK, Vinarsky V, Wain J, Zhao R, Jung K, Choi J, Lam A, Pardo-Saganta A, Breton S, Rajagopal J, Yun SH.

Am J Respir Cell Mol Biol. 2012 Dec;47(6):864-8. doi: 10.1165/rcmb.2012-0164OC. PMID: 22984086

Fabrication and operation of GRIN probes for in vivo fluorescence cellular imaging of internal organs in small animals.

Kim JK, Lee WM, Kim P, Choi M, Jung K, Kim S, Yun SH.

Nat Protoc. 2012 Jul 5;7(8):1456-69. doi: 10.1038/nprot.2012.078. PMID: 22767088

2011
2011

Double anti-angiogenic and anti-inflammatory protein Valpha targeting VEGF-A and TNF-alpha in retinopathy and psoriasis.

Jung K, Lee D, Lim HS, Lee SI, Kim YJ, Lee GM, Kim SC, Koh GY.

J Biol Chem. 2011 Apr 22;286(16):14410-8. doi: 10.1074/jbc.M111.228130. PMID: 21345791

2010
2010

Double antiangiogenic protein, DAAP, targeting VEGF-A and angiopoietins in tumor angiogenesis, metastasis, and vascular leakage.

Koh YJ, Kim HZ, Hwang SI, Lee JE, Oh N, Jung K, Kim M, Kim KE, Kim H, Lim NK, Jeon CJ, Lee GM, Jeon BH, Nam DH, Sung HK, Nagy A, Yoo OJ, Koh GY.

Cancer Cell. 2010 Aug 9;18(2):171-84. doi: 10.1016/j.ccr.2010.07.001. PMID: 20708158

2009
2009

Toll-like receptor 4 decoy, TOY, attenuates gram-negative bacterial sepsis.

Jung K, Lee JE, Kim HZ, Kim HM, Park BS, Hwang SI, Lee JO, Kim SC, Koh GY.

PLoS One. 2009 Oct 9;4(10):e7403. doi: 10.1371/journal.pone.0007403. PMID: 19816595

Critical role of CD11b+ macrophages and VEGF in inflammatory lymphangiogenesis, antigen clearance, and inflammation resolution.

Kataru RP, Jung K, Jang C, Yang H, Schwendener RA, Baik JE, Han SH, Alitalo K, Koh GY.

Blood. 2009 May 28;113(22):5650-9. doi: 10.1182/blood-2008-09-176776. PMID: 19346498

A designed angiopoietin-2 variant, pentameric COMP-Ang2, strongly activates Tie2 receptor and stimulates angiogenesis.

Kim HZ, Jung K, Kim HM, Cheng Y, Koh GY.

Biochim Biophys Acta. 2009 May;1793(5):772-80. doi: 10.1016/j.bbamcr.2009.01.018. PMID: 19339208

2008
2008

Profound but dysfunctional lymphangiogenesis via vascular endothelial growth factor ligands from CD11b+ macrophages in advanced ovarian cancer.

Jeon BH, Jang C, Han J, Kataru RP, Piao L, Jung K, Cha HJ, Schwendener RA, Jang KY, Kim KS, Alitalo K, Koh GY.

Cancer Res. 2008 Feb 15;68(4):1100-9. doi: 10.1158/0008-5472.CAN-07-2572. PMID: 18281485

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