Our Science
Cancer Immunology and In Vivo Imaging
Immune Microenvironment
in Cancers
In Vivo Imaging
Drug Development
Research
[Cancer Immunology]
In recent years, oncology research has seen immense progress due to the development of cancer immunology. Our lab has contributed to this revolution by discovering the vital role of myeloid cells in the tumor microenvironment, a previously unexplored area. We are currently leading the task of unveiling the immense potential of myeloid cells in cancers.
Relevant Papers
Jeong et al., 2021, Immune Network.
Jeong et al., 2019, Frontiers in Immunol.
Jung et al., 2017, Proc Natl Acad Sci U S A.
Jung et al., 2017, J Clin Invest.
[Single-Cell Genomics]
Single-cell RNA sequencing is an innovative experimental technique that allows the acquisition of genetic information for each individual cell. This is an optimal method for effectively performing phenotypic/functional classification between various cells in the tumor microenvironment. Through single-cell RNA sequencing analysis for different cancer types, we aim to discover novel therapeutic targets by conducting in-depth analyses of cell functions, differentiation processes, and interactions between populations inside the tumor microenvironment.
Relevant Papers
Kim et al., 2022, Nat. Commun.
Kim et al., 2022. Nucleic Acids Res.
[In Vivo Imaging]
Furthermore, our lab utilizes intravital multi-photon microscopy to examine "real-life phenomena" that cannot be seen through conventional methods. With this state-of-the-art tool, we are able to conduct novel research by observing biological processes in living organisms, thus setting us apart from other labs.
Relevant Papers
Choo et al., 2020, BMB Reports.
Jung et al., 2017, J Clin Invest.
Recombinant Protein Engineering
siRNA delivery using nanoparticles
[Drug Development]
The aforementioned use of cutting-edge imaging platforms allows us to delve into cancer immunology.
Our lab is interested in not only nurturing the basic sciences, but also advancing clinical research through drug development. Collaboration with the plethora of competent clinical doctors on campus will lead us to this end, especially in the field of translational medicine.
Relevant Papers
Kim et al., 2022, Nat. Commun.
Lee et al., 2021, Chem. Mater.
Jung et al., 2017, Proc Natl Acad Sci U S A.
Keywords
cancer immunology, in vivo imaging, single-cell genomics, vascular biology, tumor microenvironment, intravital multi-photon microscopy, drug development